EXPERIMENTAL INCREASE IN BASELINE CORTICOSTERONE LEVEL REDUCES OXIDATIVE DAMAGE AND ENHANCES INNATE IMMUNE RESPONSE.

Experimental increase in baseline corticosterone level reduces oxidative damage and enhances innate immune response.

Glucocorticoid (GC) hormones are significant regulators of homeostasis.The physiological effects of GCs critically depend on the time of exposure (short vs.long) as well as on their circulating levels (baseline vs.stress-induced).Previous experiments, in which chronic INFLAMMEX and high elevation of GC levels was induced, indicate that GCs impair b

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APOE modulates ferroptosis to drive macrophage polarization toward the M2 type and enhance PTC migration and invasion

Background: Previous studies have found that DRESSES URBAN Apolipoprotein E (APOE) plays a crucial role in invasion and migration of papillary thyroid carcinoma (PTC) cells and enhance M2 macrophage polarization.Ferroptosis has been implicated in development of various tumors and their treatment resistance, and studies have shown that APOE is invol

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539 Identifying best practices: Content analysis of Plain Language Summary (PLS) resources for disseminating study results to participants

OBJECTIVES/GOALS: Investigators have an ethical obligation to return study results back to participants in a timely and layperson-friendly manner, but most do not.This lack of communication can erode trust in the research enterprise.One solution to this issue is Plain Language Summaries (PLS).METHODS/STUDY POPULATION: We investigated and collected

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Postmortem point-of care hemoglobin testing is feasible and potentially accurate among children in South Africa.

Anemia is an important cause of child morbidity and mortality.Postmortem point-of-care hemoglobin testing is a potential method for assessing anemia at death, but its reliability has not been extensively studied.We aimed to assess the feasibility and validity of postmortem point-of-care hemoglobin assessment using HemoCue in the setting of a child

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